ANGPTL7

Across TCGA cell cohorts, ANGPTL7 mutation is significantly associated with the mutation status of many other genes, with 312 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANGPTL7-associated genes across cancer lineages are PNLIPRP1, PAX9, and TG. Each is linked with ANGPTL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL7-to-partner and partner-to-ANGPTL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNLIPRP1 grouped by ANGPTL7-low versus ANGPTL7-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL7→partner) and Y-score (partner→ANGPTL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PNLIPRP1 →	+3.638	+4.117	.002	.002	1	2
SKIN	PAX9 →	+5.053	+4.239	.007	.007	1	2
LARGE_INTESTINE	TG →	+1.366	+2.630	.008	.008	1	2
LARGE_INTESTINE	WDR3 →	+1.691	+2.479	.008	.008	1	2
LARGE_INTESTINE	WSCD2 →	+3.029	+3.989	<.001	<.001	1	2
LARGE_INTESTINE	LRCH4 →	+2.807	+2.678	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 312 associations by consensus.

PNLIPRP1 by ANGPTL7 expression — SKIN

Explore this box plot interactively →