ANGPTL6

Across TCGA patient cohorts, ANGPTL6 protein abundance is significantly associated with the RNA expression of many other genes, with 2,641 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ANGPTL6-associated genes across cancer lineages are CDH20, DLX5, and MYL7. Each is linked with ANGPTL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL6-to-partner and partner-to-ANGPTL6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGPTL6 versus CDH20 in BRCA, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL6→partner) and Y-score (partner→ANGPTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDH20 →	+0.249	+0.860	<.001	.006	3	1
BRCA	DLX5 →	+1.124	+0.860	.009	.006	3	1
BRCA	MYL7 →	+2.473	+0.861	<.001	.006	3	1
BRCA	RAB11FIP2 →	+0.679	+0.860	<.001	.006	3	1
BRCA	NDUFC1 →	+0.933	+1.163	.003	.008	3	1
BRCA	KLHL2 →	+1.265	+0.860	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,641 associations by consensus.

ANGPTL6 vs CDH20 — BRCA

Explore this scatter interactively →