ANGPTL6

Across TCGA cell cohorts, ANGPTL6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,112 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ANGPTL6-associated GO terms across cancer lineages are Actin filament depolymerization, Negative regulation of respiratory burst involved in inflammatory response, and Negative regulation of respiratory burst. Each is linked with ANGPTL6 in more than 6 cancer types. Because this analysis shows association rather than direction, both ANGPTL6-to-partner and partner-to-ANGPTL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by ANGPTL6-low versus ANGPTL6-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL6→partner) and Y-score (partner→ANGPTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.200	+0.331	<.001	.009	3	7
BLOOD_Lymphoma	Negative regulation of respiratory burst involved in inflammatory response →	+0.089	+1.294	.006	<.001	3	7
BLOOD_Lymphoma	Negative regulation of respiratory burst →	+0.089	+1.294	.006	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	ATP synthesis coupled electron transport →	+0.074	+0.143	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Mitochondrial ATP synthesis coupled electron transport →	+0.074	+0.143	<.001	.001	3	7
SKIN	Purine nucleoside triphosphate metabolic process →	+0.076	+0.698	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,112 associations by consensus.

Actin filament depolymerization by ANGPTL6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →