ANGPTL6

Across TCGA cell cohorts, ANGPTL6 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANGPTL6-associated genes across cancer lineages are C10orf53, FAM205A, and NEXMIF. Each is linked with ANGPTL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL6-to-partner and partner-to-ANGPTL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by ANGPTL6-low versus ANGPTL6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL6→partner) and Y-score (partner→ANGPTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
LARGE_INTESTINE	NEXMIF →	+0.264	+3.196	<.001	.007	3	1
SKIN	CELA3B →	+0.042	+5.415	<.001	.004	3	1
BLOOD_Leukemia	PPP1R2C →	+0.230	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CST8 →	+0.046	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C10orf53 by ANGPTL6 expression — LARGE_INTESTINE

Explore this box plot interactively →