Across TCGA patient cohorts, ANGPTL5 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL5-associated genes across cancer lineages are PCNA, Shc_pY317, and EGFR_pY1068. Each is linked with ANGPTL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANGPTL5-to-partner and partner-to-ANGPTL5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL5→partner) and Y-score (partner→ANGPTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.279	+2.807	.003	.003	3	3
UCEC	Shc_pY317 →	-0.135	-2.321	.042	.034	3	2
UCEC	EGFR_pY1068 →	-0.283	-3.906	.009	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-3.459	.022	.005	3	1
UCEC	NF-kB-p65_pS536 →	-0.527	-3.169	.007	.018	3	1
UCEC	PDCD4 →	-0.683	-2.115	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

ANGPTL5 survival (RNA) · tumor vs normal (RNA) · all ANGPTL5 data types