ANGPTL4

Across TCGA patient cohorts, ANGPTL4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,765 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ANGPTL4-associated genes across cancer lineages are SLC2A1, VEGFA, and TMEM45A. Each is linked with ANGPTL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ANGPTL4-to-partner and partner-to-ANGPTL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGPTL4 versus SLC2A1 in LUAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL4→partner) and Y-score (partner→ANGPTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC2A1 →	+1.253	+0.969	<.001	<.001	3	7
GBM	VEGFA →	+1.333	+1.240	<.001	<.001	3	7
CCRCC	TMEM45A →	+1.152	+0.586	<.001	<.001	3	7
PDAC	ERO1A →	+1.240	+1.231	<.001	<.001	3	7
HNSC	PGK1 →	+1.366	+0.761	<.001	<.001	3	6
OV	SERPINE1 →	+1.797	+1.009	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,765 associations by consensus.

ANGPTL4 vs SLC2A1 — LUAD

Explore this scatter interactively →