ANGPTL4

Across TCGA patient cohorts, ANGPTL4 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible ANGPTL4-associated genes across cancer lineages are Megakaryocytes, Preadipocytes, and CD8+ naive T-cells. Each is linked with ANGPTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL4-to-partner and partner-to-ANGPTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Megakaryocytes grouped by ANGPTL4-low versus ANGPTL4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL4→partner) and Y-score (partner→ANGPTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Megakaryocytes →	+0.019	+3.244	.015	.020	3	1
BLCA	Preadipocytes →	+0.028	+4.527	.033	.017	3	1
UCEC	CD8+ naive T-cells →	+0.028	+3.032	.032	.018	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Megakaryocytes by ANGPTL4 expression — LUSC

Explore this box plot interactively →