ANGPTL4

Across TCGA cell cohorts, ANGPTL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,628 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ANGPTL4-associated GO terms across cancer lineages are Regulation of chylomicron remodeling, Regulation of very-low-density lipoprotein particle remodeling, and Negative regulation of very-low-density lipoprotein particle remodeling. Each is linked with ANGPTL4 in more than 18 cancer types. Because this analysis shows association rather than direction, both ANGPTL4-to-partner and partner-to-ANGPTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chylomicron remodeling grouped by ANGPTL4-low versus ANGPTL4-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL4→partner) and Y-score (partner→ANGPTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of chylomicron remodeling →	+1.992	+3.080	<.001	<.001	3	19
LUNG_NSCLC_LUAD	Regulation of very-low-density lipoprotein particle remodeling →	+1.919	+2.723	<.001	<.001	3	15
LUNG_NSCLC_LUAD	Negative regulation of very-low-density lipoprotein particle remodeling →	+1.903	+2.709	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of cardiac muscle adaptation →	+0.329	+2.395	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Negative regulation of cardiac muscle hypertrophy in response to stress →	+0.329	+2.395	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of cardiac muscle adaptation →	+0.338	+2.395	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,628 associations by consensus.

Regulation of chylomicron remodeling by ANGPTL4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →