ANGPTL3

Across TCGA pan-cancer cohorts, ANGPTL3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ANGPTL3 data layer compared with 18 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ANGPTL3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ANGPTL3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where ANGPTL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.953	0.494	.001	40	view →
PDAC	DFS	Quartile	II,III,IV	0.288	0.849	.024	8	view →
CCRCC	OS	Median	All	1.000	0.911	.023	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ANGPTL3–LSCC (DFS)

Open the LSCC breakdown →