ANGPTL3

Across TCGA patient cohorts, ANGPTL3 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,755 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ANGPTL3-associated proteins across cancer lineages are DOCK7, HNRNPLL, and CTPS2. Each is linked with ANGPTL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANGPTL3-to-partner and partner-to-ANGPTL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGPTL3 versus DOCK7 in HNSC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL3→partner) and Y-score (partner→ANGPTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DOCK7 →	+0.288	+0.720	<.001	<.001	3	4
HNSC	HNRNPLL →	+0.215	+0.536	.001	.001	3	4
HNSC	CTPS2 →	+0.285	+0.543	<.001	<.001	3	3
PDAC	DOCK7_S888 →	+0.617	+0.306	.006	.001	3	3
PDAC	AKAP13_S2699 →	+0.678	+0.365	<.001	<.001	3	3
PDAC	KLC4 →	+0.308	+0.278	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,755 associations by consensus.

ANGPTL3 vs DOCK7 — HNSC

Explore this scatter interactively →