ANGPTL3

Across TCGA patient cohorts, ANGPTL3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,549 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ANGPTL3-associated genes across cancer lineages are DCN, CDKN1A, and SNORA53. Each is linked with ANGPTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL3-to-partner and partner-to-ANGPTL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGPTL3 versus DCN in CCRCC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL3→partner) and Y-score (partner→ANGPTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DCN →	+1.441	+0.577	.003	<.001	3	2
LSCC	CDKN1A →	+0.749	+0.495	.001	.003	3	2
CCRCC	SNORA53 →	-0.908	-0.617	<.001	.003	3	2
CCRCC	TMEM132A →	+0.554	+0.508	.006	.003	3	2
PDAC	RNA5SP26 →	+1.261	+0.989	<.001	.001	3	2
BRCA	DNAJB6P1 →	+1.289	+1.123	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,549 associations by consensus.

ANGPTL3 vs DCN — CCRCC

Explore this scatter interactively →