ANGPTL3

Across TCGA patient cohorts, ANGPTL3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL3-associated genes across cancer lineages are Gab2, MSH2, and Notch1. Each is linked with ANGPTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL3-to-partner and partner-to-ANGPTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by ANGPTL3-low versus ANGPTL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL3→partner) and Y-score (partner→ANGPTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.379	+1.906	.008	.016	3	1
UCEC	MSH2 →	-0.193	-2.433	.037	.018	3	1
UCEC	Notch1 →	+0.147	+2.469	.009	.010	3	1
UCEC	Annexin-1 →	+0.645	+3.479	.002	.002	3	1
UCEC	Caspase-8 →	-0.201	-2.558	.047	.010	3	1
UCEC	Cyclin-B1 →	+0.517	+2.415	.022	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Gab2 by ANGPTL3 expression — UCEC

Explore this box plot interactively →