ANGPTL3

Across TCGA cell cohorts, ANGPTL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,987 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANGPTL3-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Microtubule polymerization, and Protein localization to chromosome, telomeric region. Each is linked with ANGPTL3 in more than 7 cancer types. Because this analysis shows association rather than direction, both ANGPTL3-to-partner and partner-to-ANGPTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by ANGPTL3-low versus ANGPTL3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL3→partner) and Y-score (partner→ANGPTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.096	+0.065	<.001	<.001	3	8
BLOOD_Leukemia	Microtubule polymerization →	+0.092	+0.062	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Protein localization to chromosome, telomeric region →	+0.099	+0.121	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.122	+0.090	<.001	.006	3	7
SOFT_TISSUE	Metaphase/anaphase transition of cell cycle →	+0.106	+0.089	.001	<.001	3	7
BLOOD_Leukemia	Positive regulation of DNA metabolic process →	+0.057	+0.109	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,987 associations by consensus.

Subtelomeric heterochromatin formation by ANGPTL3 expression — SOFT_TISSUE

Explore this box plot interactively →