ANGPTL3

Across TCGA cell cohorts, ANGPTL3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANGPTL3-associated genes across cancer lineages are OR12D3, TOPAZ1, and ARGFX. Each is linked with ANGPTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL3-to-partner and partner-to-ANGPTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by ANGPTL3-low versus ANGPTL3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL3→partner) and Y-score (partner→ANGPTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR12D3 →	+0.056	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TOPAZ1 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.032	+5.662	<.001	.002	3	1
STOMACH	TRPC5 →	+0.006	+3.632	.001	.009	3	1
LARGE_INTESTINE	TNP1 →	+0.131	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR12D3 by ANGPTL3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →