ANGPTL2

Across TCGA pan-cancer cohorts, ANGPTL2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ANGPTL2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ANGPTL2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ANGPTL2 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

CCRCC, PDAC, and COAD are the cancer types where ANGPTL2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANGPTL2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+1.061	<.001	11	view →
PDAC	Male	All	+1.248	<.001	10	view →
COAD	Female	All	−0.559	<.001	9	view →
LUAD	Male	All	+0.325	<.001	6	view →
LSCC	All	All	+0.193	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ANGPTL2–CCRCC

Open the CCRCC breakdown →