ANGPTL1

Across TCGA patient cohorts, ANGPTL1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,464 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ANGPTL1-associated genes across cancer lineages are MAL2, FIBIN, and MIR3128. Each is linked with ANGPTL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANGPTL1-to-partner and partner-to-ANGPTL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGPTL1 versus MAL2 in LSCC, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL1→partner) and Y-score (partner→ANGPTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAL2 →	-1.001	-0.421	<.001	.003	3	3
BRCA	FIBIN →	+1.760	+1.451	.006	.007	3	3
UCEC	MIR3128 →	-1.472	-0.944	<.001	.001	3	3
OV	RBM17 →	-0.690	-1.024	.001	<.001	3	2
PDAC	PPP1R1A →	+1.173	+0.729	.001	<.001	3	2
OV	NUP54 →	-0.434	-0.931	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,464 associations by consensus.

ANGPTL1 vs MAL2 — LSCC

Explore this scatter interactively →