ANGPTL1

Across TCGA patient cohorts, ANGPTL1 mutation is significantly associated with the RNA expression of many other genes, with 1,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL1-associated genes across cancer lineages are GZMB, IFNG, and RWDD1. Each is linked with ANGPTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL1-to-partner and partner-to-ANGPTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMB grouped by ANGPTL1-low versus ANGPTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL1→partner) and Y-score (partner→ANGPTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GZMB →	+1.001	+3.584	.004	.002	3	2
UCEC	IFNG →	+0.738	+3.111	<.001	<.001	3	2
UCEC	RWDD1 →	+0.469	+2.423	<.001	.001	3	2
UCEC	COX7A2 →	+0.327	+2.287	.006	.005	3	2
UCEC	RTN4IP1 →	+0.403	+2.447	<.001	.001	3	2
UCEC	METTL5 →	+0.440	+1.947	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,586 associations by consensus.

GZMB by ANGPTL1 expression — UCEC

Explore this box plot interactively →