ANGPT2

Across TCGA pan-cancer cohorts, ANGPT2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ANGPT2 data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ANGPT2 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ANGPT2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, THCA, and LIHC are the cancer types where ANGPT2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.313	.001	36	view →
THCA	DFS	Median	All	0.049	0.828	<.001	24	view →
LIHC	DFS	Median	All	0.038	0.553	<.001	12	view →
LUSC	OS	Median	All	0.176	0.724	.018	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ANGPT2–UCEC (OS)

Open the UCEC breakdown →