ANGPT2

Across TCGA patient cohorts, ANGPT2 mutation is significantly associated with the RNA expression of many other genes, with 3,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPT2-associated genes across cancer lineages are RNA5SP85, RNU1-136P, and LINC02840. Each is linked with ANGPT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANGPT2-to-partner and partner-to-ANGPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP85 grouped by ANGPT2-low versus ANGPT2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT2→partner) and Y-score (partner→ANGPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP85 →	+0.214	+4.384	<.001	.008	3	2
CESC	RNU1-136P →	+0.518	+3.914	<.001	.007	3	2
CESC	LINC02840 →	+0.104	+3.653	.002	.009	3	2
CESC	NRON →	+0.158	+3.874	<.001	.006	3	2
CESC	LINC02179 →	+0.012	+4.127	<.001	.003	3	2
CESC	MIR4478 →	+1.205	+3.996	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,732 associations by consensus.

RNA5SP85 by ANGPT2 expression — CESC

Explore this box plot interactively →