ANGPT2

Across TCGA cell cohorts, ANGPT2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANGPT2-associated genes across cancer lineages are SMIM28, PPP1R17, and SPHKAP. Each is linked with ANGPT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPT2-to-partner and partner-to-ANGPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM28 grouped by ANGPT2-low versus ANGPT2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT2→partner) and Y-score (partner→ANGPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMIM28 →	+0.038	+5.228	<.001	.005	3	1
LARGE_INTESTINE	PPP1R17 →	+0.108	+4.467	<.001	.004	3	1
LARGE_INTESTINE	SPHKAP →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FCGR3B →	+0.254	+4.467	<.001	.004	3	1
LARGE_INTESTINE	GKN1 →	+0.047	+4.095	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SMIM28 by ANGPT2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →