ANGPT1

Across TCGA pan-cancer cohorts, ANGPT1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ANGPT1 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher ANGPT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ANGPT1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

ESCA, SKCM, and UCEC are the cancer types where ANGPT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	30	view →
SKCM	OS	Median	III,IV	0.279	0.745	<.001	13	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	II,III,IV	0.145	0.709	.003	3	view →
BLCA	DFS	Median	III,IV	1.000	0.429	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ANGPT1–ESCA (OS)

Open the ESCA breakdown →