ANGPT1

Across TCGA patient cohorts, ANGPT1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,696 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ANGPT1-associated genes across cancer lineages are SLC8A3, CD40LG, and FGD1. Each is linked with ANGPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPT1-to-partner and partner-to-ANGPT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGPT1 versus SLC8A3 in LUAD, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT1→partner) and Y-score (partner→ANGPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC8A3 →	+0.284	+0.331	.001	.007	3	2
LSCC	CD40LG →	+0.448	+0.347	<.001	<.001	3	2
LSCC	FGD1 →	-0.525	-0.316	<.001	.001	3	2
LSCC	HTR2A →	+0.375	+0.541	.001	<.001	3	2
LUAD	ASF1B →	-0.757	-0.263	<.001	.005	3	2
LUAD	HOXA5 →	+0.545	+0.372	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,696 associations by consensus.

ANGPT1 vs SLC8A3 — LUAD

Explore this scatter interactively →