ANGPT1

Across TCGA patient cohorts, ANGPT1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPT1-associated genes across cancer lineages are TFRC, ASNS, and Annexin-1. Each is linked with ANGPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPT1-to-partner and partner-to-ANGPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ANGPT1-low versus ANGPT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT1→partner) and Y-score (partner→ANGPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.641	+3.321	.002	.010	3	2
SKCM	ASNS →	+0.293	+1.289	.034	.022	3	2
UCEC	Annexin-1 →	+0.476	+3.341	.024	.005	3	2
SKCM	ACC_pS79 →	+0.257	+2.169	.005	.002	3	1
SKCM	ACC1 →	+0.285	+2.012	.003	.004	3	1
SKCM	p90 RSK →	+0.167	+1.700	.012	.038	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

TFRC by ANGPT1 expression — UCEC

Explore this box plot interactively →