ANGPT1

Across TCGA cell cohorts, ANGPT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,834 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ANGPT1-associated GO terms across cancer lineages are Tie signaling pathway, Activation of transmembrane receptor protein tyrosine kinase activity, and Regulation of blood-brain barrier permeability. Each is linked with ANGPT1 in more than 18 cancer types. Because this analysis shows association rather than direction, both ANGPT1-to-partner and partner-to-ANGPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tie signaling pathway grouped by ANGPT1-low versus ANGPT1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT1→partner) and Y-score (partner→ANGPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Tie signaling pathway →	+1.641	+2.847	<.001	<.001	3	19
PANCREAS	Activation of transmembrane receptor protein tyrosine kinase activity →	-0.482	-0.939	.008	<.001	3	14
LUNG_NSCLC_LUAD	Regulation of blood-brain barrier permeability →	-0.265	-1.531	<.001	<.001	3	8
STOMACH	Positive regulation of blood-brain barrier permeability →	-0.288	-1.829	<.001	.005	3	8
STOMACH	Translational initiation →	+0.085	+2.282	.002	.004	3	8
BONE	Regulation of cell-substrate junction organization →	+0.160	+2.126	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,834 associations by consensus.

Tie signaling pathway by ANGPT1 expression — SKIN

Explore this box plot interactively →