ANGPT1

Across TCGA cell cohorts, ANGPT1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANGPT1-associated genes across cancer lineages are FGF6, APOBEC1, and SEMG2. Each is linked with ANGPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPT1-to-partner and partner-to-ANGPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by ANGPT1-low versus ANGPT1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT1→partner) and Y-score (partner→ANGPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FGF6 →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	APOBEC1 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SEMG2 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CEACAM8 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPANXN4 →	+0.156	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR5K4 →	+0.023	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FGF6 by ANGPT1 expression — BLOOD_Myeloma

Explore this box plot interactively →