ANGEL2

Across TCGA pan-cancer cohorts, ANGEL2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ANGEL2 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ANGEL2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ANGEL2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, KIRC, and PRAD are the cancer types where ANGEL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.620	.010	30	view →
KIRC	OS	Median	All	0.181	0.655	.046	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUSC	OS	Median	All	0.196	0.724	.049	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →
GBM	DFS	Median	All	1.000	0.192	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ANGEL2–UCEC (DFS)

Open the UCEC breakdown →