ANGEL2

Across TCGA patient cohorts, ANGEL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,105 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ANGEL2-associated proteins across cancer lineages are RCOR3, BROX, and CHAMP1. Each is linked with ANGEL2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ANGEL2-to-partner and partner-to-ANGEL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGEL2 versus RCOR3 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL2→partner) and Y-score (partner→ANGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCOR3 →	+0.383	+0.412	<.001	<.001	3	7
BRCA	BROX →	+0.442	+0.599	<.001	<.001	3	7
GBM	CHAMP1 →	+0.374	+0.307	<.001	<.001	3	7
GBM	GATAD2B →	+0.376	+0.399	<.001	<.001	3	7
PDAC	S100A12 →	-1.158	-0.267	<.001	.004	3	6
LSCC	DDX59 →	+0.371	+0.509	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,105 associations by consensus.

ANGEL2 vs RCOR3 — LSCC

Explore this scatter interactively →