ANGEL2

Across TCGA patient cohorts, ANGEL2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,003 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ANGEL2-associated genes across cancer lineages are MYEF2, RALGPS1, and FLVCR1. Each is linked with ANGEL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANGEL2-to-partner and partner-to-ANGEL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANGEL2 versus MYEF2 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL2→partner) and Y-score (partner→ANGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYEF2 →	+0.832	+0.330	.001	<.001	3	5
LSCC	RALGPS1 →	+0.596	+0.216	<.001	<.001	3	5
LSCC	FLVCR1 →	+0.618	+0.279	<.001	<.001	3	5
LUAD	ZNRF3 →	+0.635	+0.245	<.001	<.001	3	5
BRCA	NOS1AP →	+1.080	+0.359	<.001	<.001	3	5
HNSC	COX20 →	+0.594	+0.220	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,003 associations by consensus.

ANGEL2 vs MYEF2 — BRCA

Explore this scatter interactively →