ANGEL2

Across TCGA cell cohorts, ANGEL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,245 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANGEL2-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum membrane, Negative regulation of tRNA metabolic process, and RNA 3'-end processing. Each is linked with ANGEL2 in more than 16 cancer types. Because this analysis shows association rather than direction, both ANGEL2-to-partner and partner-to-ANGEL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum membrane grouped by ANGEL2-low versus ANGEL2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL2→partner) and Y-score (partner→ANGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Establishment of protein localization to endoplasmic reticulum membrane →	+0.107	+0.765	<.001	<.001	3	17
OVARY	Negative regulation of tRNA metabolic process →	+0.138	+0.995	<.001	<.001	3	16
OVARY	RNA 3'-end processing →	+0.077	+0.996	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Subtelomeric heterochromatin formation →	+0.117	+0.923	<.001	<.001	2	15
BLOOD_Myeloma	Regulation of maintenance of sister chromatid cohesion →	+0.108	+1.009	<.001	<.001	3	14
BLOOD_Myeloma	Regulation of maintenance of mitotic sister chromatid cohesion →	+0.108	+1.009	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,245 associations by consensus.

Establishment of protein localization to endoplasmic reticulum membrane by ANGEL2 expression — STOMACH

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