ANGEL2

Across TCGA cell cohorts, ANGEL2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ANGEL2-associated genes across cancer lineages are ITGAD, CCDC195, and SCGB1C1. Each is linked with ANGEL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGEL2-to-partner and partner-to-ANGEL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by ANGEL2-low versus ANGEL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL2→partner) and Y-score (partner→ANGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.012	+3.247	<.001	.001	3	1
LARGE_INTESTINE	CCDC195 →	+0.029	+2.882	.008	.005	3	1
BREAST	SCGB1C1 →	+0.074	+5.169	<.001	.005	3	1
SKIN	TMEM114 →	+0.065	+4.977	<.001	.007	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
SKIN	RFX6 →	+0.053	+5.029	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ITGAD by ANGEL2 expression — LARGE_INTESTINE

Explore this box plot interactively →