ANGEL1

Across TCGA patient cohorts, ANGEL1 mutation is significantly associated with the RNA expression of many other genes, with 2,699 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGEL1-associated genes across cancer lineages are RNU6-1318P, CWC25, and FRG1HP. Each is linked with ANGEL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANGEL1-to-partner and partner-to-ANGEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by ANGEL1-low versus ANGEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL1→partner) and Y-score (partner→ANGEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1318P →	+0.222	+2.221	<.001	.005	3	3
UCEC	CWC25 →	+0.380	+3.053	.001	<.001	3	2
UCEC	FRG1HP →	+0.409	+1.839	.003	.002	3	2
SKCM	AP2B1P1 →	+0.131	+2.254	.008	.006	3	2
SKCM	RPL22P7 →	+0.093	+2.178	.005	.001	3	2
SKCM	ANK2-AS1 →	+0.038	+2.331	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,699 associations by consensus.

RNU6-1318P by ANGEL1 expression — UCEC

Explore this box plot interactively →