ANGEL1

Across TCGA patient cohorts, ANGEL1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGEL1-associated genes across cancer lineages are Annexin-1, ERK2, and p27_pT198. Each is linked with ANGEL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANGEL1-to-partner and partner-to-ANGEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ANGEL1-low versus ANGEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL1→partner) and Y-score (partner→ANGEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.644	+2.584	.001	.010	3	3
UCEC	ERK2 →	+0.179	+1.765	.013	.014	3	2
UCEC	p27_pT198 →	+0.086	+1.415	.032	.046	3	2
UCEC	Rab25 →	-0.304	-1.415	.014	.046	3	2
UCEC	STAT3_pY705 →	-0.343	-1.896	<.001	.015	3	2
UCEC	Tuberin_pT1462 →	+0.189	+1.594	.029	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Annexin-1 by ANGEL1 expression — UCEC

Explore this box plot interactively →