ANGEL1

Across TCGA cell cohorts, ANGEL1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANGEL1-associated genes across cancer lineages are LRRC3C, GML, and C20orf85. Each is linked with ANGEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGEL1-to-partner and partner-to-ANGEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by ANGEL1-low versus ANGEL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL1→partner) and Y-score (partner→ANGEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.263	+4.144	<.001	<.001	3	2
BLOOD_Leukemia	GML →	+0.078	+4.152	<.001	.009	3	1
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1
BLOOD_Leukemia	COX4I2 →	+0.522	+4.276	<.001	.007	3	1
BLOOD_Leukemia	LRIT1 →	+0.046	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

LRRC3C by ANGEL1 expression — LARGE_INTESTINE

Explore this box plot interactively →