ANAPC5

Across TCGA patient cohorts, ANAPC5 mutation is significantly associated with the RNA expression of many other genes, with 2,649 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC5-associated genes across cancer lineages are DSCR4, IGHD6-6, and RNA5SP162. Each is linked with ANAPC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANAPC5-to-partner and partner-to-ANAPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR4 grouped by ANAPC5-low versus ANAPC5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC5→partner) and Y-score (partner→ANAPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DSCR4 →	+1.674	+4.790	<.001	<.001	3	3
LUSC	IGHD6-6 →	+1.432	+3.954	.003	.003	3	3
CESC	RNA5SP162 →	+1.320	+5.103	<.001	.008	3	3
COAD	GFY →	+0.302	+3.663	.005	.007	3	3
UCEC	STAU2P1 →	+0.126	+1.853	<.001	<.001	3	3
SKCM	ZNF8 →	+0.455	+3.331	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,649 associations by consensus.

DSCR4 by ANAPC5 expression — LUAD

Explore this box plot interactively →