ANAPC5

Across TCGA patient cohorts, ANAPC5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC5-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and Shc_pY317. Each is linked with ANAPC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC5-to-partner and partner-to-ANAPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ANAPC5-low versus ANAPC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC5→partner) and Y-score (partner→ANAPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.257	-1.765	.006	.014	3	2
UCEC	PDCD4 →	-0.459	-2.321	.009	.033	3	2
UCEC	Shc_pY317 →	-0.201	-2.169	<.001	.003	3	2
UCEC	ATM →	-0.424	-3.156	.012	.018	3	2
UCEC	beta-Catenin →	+0.379	+1.415	.046	.046	3	2
UCEC	4E-BP1 →	+0.272	+3.321	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1068 by ANAPC5 expression — UCEC

Explore this box plot interactively →