ANAPC5

Across TCGA cell cohorts, ANAPC5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANAPC5-associated genes across cancer lineages are OR2AJ1, ACSM2B, and FAM205A. Each is linked with ANAPC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC5-to-partner and partner-to-ANAPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by ANAPC5-low versus ANAPC5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC5→partner) and Y-score (partner→ANAPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2AJ1 →	+0.023	+3.867	<.001	.002	3	1
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+3.614	<.001	.006	3	1
LARGE_INTESTINE	SPESP1 →	+0.712	+3.643	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR2AJ1 by ANAPC5 expression — BLOOD_Lymphoma

Explore this box plot interactively →