ANAPC2

Across TCGA patient cohorts, ANAPC2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC2-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and Lck. Each is linked with ANAPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC2-to-partner and partner-to-ANAPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ANAPC2-low versus ANAPC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC2→partner) and Y-score (partner→ANAPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ERK2 →	+0.231	+2.832	.029	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.710	+2.906	.004	.001	3	2
COAD	Lck →	+0.559	+2.832	<.001	.035	2	2
COAD	PTEN →	+0.173	+2.815	.024	.036	3	1
UCEC	p62 Lck ligand →	+0.423	+2.594	.002	.006	3	1
UCEC	Annexin-1 →	+0.494	+2.222	.027	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ERK2 by ANAPC2 expression — COAD

Explore this box plot interactively →