ANAPC2

Across TCGA cell cohorts, ANAPC2 mutation is significantly associated with the RNA expression of many other genes, with 517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANAPC2-associated genes across cancer lineages are FBXW10, OR10K1, and GPRIN2. Each is linked with ANAPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC2-to-partner and partner-to-ANAPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by ANAPC2-low versus ANAPC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC2→partner) and Y-score (partner→ANAPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.252	+3.906	<.001	<.001	3	2
BLOOD_Leukemia	OR10K1 →	+0.342	+3.234	.005	.008	3	2
BLOOD_Leukemia	GPRIN2 →	+0.026	+4.004	.003	.002	3	2
BLOOD_Leukemia	IQCF5 →	+0.072	+4.201	<.001	.001	3	2
LARGE_INTESTINE	RASL10A →	+0.268	+3.212	.004	.006	3	1
LARGE_INTESTINE	UBXN8 →	+0.949	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 517 associations by consensus.

FBXW10 by ANAPC2 expression — LARGE_INTESTINE

Explore this box plot interactively →