ANAPC1P1

Across TCGA patient cohorts, ANAPC1P1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC1P1-associated genes across cancer lineages are MEK1_p_S217_S221, Ku80, and MEK1. Each is linked with ANAPC1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC1P1-to-partner and partner-to-ANAPC1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by ANAPC1P1-low versus ANAPC1P1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC1P1→partner) and Y-score (partner→ANAPC1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEK1_p_S217_S221 →	+0.310	+2.459	.005	.020	3	2
LUAD	Ku80 →	+0.302	+2.841	.028	.035	3	1
UCEC	MEK1 →	+0.511	+3.459	.002	.005	3	1
UCEC	p62 Lck ligand →	+0.461	+3.009	.002	.019	3	1
UCEC	PDCD4 →	-0.621	-2.584	.004	.011	3	1
UCEC	TIGAR →	+0.156	+2.611	.028	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1_p_S217_S221 by ANAPC1P1 expression — SKCM

Explore this box plot interactively →