ANAPC15

Across TCGA patient cohorts, ANAPC15 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC15-associated genes across cancer lineages are Tuberin_pT1462, ATM, and Caspase-8. Each is linked with ANAPC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC15-to-partner and partner-to-ANAPC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by ANAPC15-low versus ANAPC15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC15→partner) and Y-score (partner→ANAPC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.270	+2.817	.043	.036	3	1
UCEC	ATM →	-0.606	-3.000	.020	.037	2	1
UCEC	Caspase-8 →	-0.319	-3.000	.028	.036	2	1
UCEC	JNK_pT183_Y185 →	-0.236	-2.986	.015	.037	1	1
UCEC	TFRC →	+1.155	+3.000	<.001	.037	1	1
UCEC	C-Raf →	+0.179	+3.000	.030	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Tuberin_pT1462 by ANAPC15 expression — UCEC

Explore this box plot interactively →