ANAPC1

Across TCGA patient cohorts, ANAPC1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC1-associated genes across cancer lineages are eIF4G, FoxM1, and Notch1. Each is linked with ANAPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC1-to-partner and partner-to-ANAPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by ANAPC1-low versus ANAPC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC1→partner) and Y-score (partner→ANAPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4G →	+0.419	+2.459	.027	.020	3	2
UCEC	FoxM1 →	+0.175	+1.321	.025	.012	3	2
UCEC	Notch1 →	+0.135	+1.450	.001	.014	3	2
UCEC	Rab11 →	-0.104	-1.678	.017	.019	3	2
UCEC	Annexin_VII →	-0.086	-1.125	.040	.033	3	2
UCEC	ATM →	-0.491	-2.489	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4G by ANAPC1 expression — SKCM

Explore this box plot interactively →