ANAPC1

Across TCGA cell cohorts, ANAPC1 mutation is significantly associated with the RNA expression of many other genes, with 837 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANAPC1-associated genes across cancer lineages are ZAN, TRIM64B, and OR2L8. Each is linked with ANAPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANAPC1-to-partner and partner-to-ANAPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by ANAPC1-low versus ANAPC1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC1→partner) and Y-score (partner→ANAPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZAN →	+0.004	+4.369	<.001	.008	3	2
STOMACH	TRIM64B →	+0.007	+5.247	<.001	<.001	3	2
LUNG_NSCLC_LUAD	OR2L8 →	+0.008	+3.944	<.001	.006	3	2
LUNG_NSCLC_LUAD	SLC26A3 →	+0.033	+3.536	<.001	.001	3	2
LARGE_INTESTINE	CCDC65 →	+0.294	+3.321	.003	.003	3	2
LARGE_INTESTINE	RNF133 →	+0.174	+2.215	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 837 associations by consensus.

ZAN by ANAPC1 expression — SOFT_TISSUE

Explore this box plot interactively →