Across TCGA patient cohorts, AMZ2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMZ2-associated genes across cancer lineages are EGFR_pY1068, ERK2, and ACC_pS79. Each is linked with AMZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMZ2-to-partner and partner-to-AMZ2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMZ2→partner) and Y-score (partner→AMZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.244	-2.222	.021	.011	3	1
UCEC	ERK2 →	+0.185	+1.700	.023	.044	3	1
UCEC	ACC_pS79 →	+0.356	+3.169	.015	.018	3	1
UCEC	JNK2 →	+0.239	+1.884	.004	.030	3	1
UCEC	MEK1 →	+0.386	+3.321	.012	.010	3	1
UCEC	mTOR_pS2448 →	-0.134	-3.150	.034	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

AMZ2 survival (RNA) · tumor vs normal (RNA) · all AMZ2 data types