AMZ1

Across TCGA patient cohorts, AMZ1 mutation is significantly associated with the RNA expression of many other genes, with 438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMZ1-associated genes across cancer lineages are PRAMEF1, C1QBPP1, and LINC02620. Each is linked with AMZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMZ1-to-partner and partner-to-AMZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF1 grouped by AMZ1-low versus AMZ1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMZ1→partner) and Y-score (partner→AMZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PRAMEF1 →	+0.092	+3.345	.004	.008	3	2
COAD	C1QBPP1 →	+0.102	+3.283	<.001	.007	3	2
COAD	LINC02620 →	+0.261	+2.847	<.001	.007	3	2
COAD	RPL19P18 →	+0.179	+2.785	<.001	.005	3	2
COAD	SNRPCP14 →	+0.426	+3.463	<.001	<.001	3	2
LUAD	RNU6-416P →	+0.369	+4.888	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 438 associations by consensus.

PRAMEF1 by AMZ1 expression — CESC

Explore this box plot interactively →