AMZ1

Across TCGA patient cohorts, AMZ1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible AMZ1-associated genes across cancer lineages are MEK1, Chk2, and ER-alpha. Each is linked with AMZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMZ1-to-partner and partner-to-AMZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by AMZ1-low versus AMZ1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMZ1→partner) and Y-score (partner→AMZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.252	+2.832	.021	.035	3	2
SKCM	Chk2 →	+0.380	+3.000	.003	.036	3	1
UCEC	ER-alpha →	+1.215	+3.459	.003	.005	3	1
UCEC	AMPK_pT172 →	+0.579	+3.472	.004	.002	3	1
COAD	PREX1 →	+0.280	+2.832	.014	.035	2	1
UCEC	Di-Ras3 →	-0.156	-2.321	.036	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by AMZ1 expression — COAD

Explore this box plot interactively →