AMZ1

Across TCGA cell cohorts, AMZ1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMZ1-associated genes across cancer lineages are KRTAP11-1, MYL10, and RXRG. Each is linked with AMZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMZ1-to-partner and partner-to-AMZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP11-1 grouped by AMZ1-low versus AMZ1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMZ1→partner) and Y-score (partner→AMZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP11-1 →	+0.083	+4.222	<.001	.006	3	1
BLOOD_Leukemia	MYL10 →	+0.015	+4.247	<.001	.004	3	1
BLOOD_Leukemia	RXRG →	+0.156	+3.675	<.001	.003	3	1
BLOOD_Leukemia	CRH →	+0.097	+3.814	.005	.002	3	1
BLOOD_Leukemia	ADCY8 →	+0.018	+3.556	.001	.001	3	1
BLOOD_Leukemia	SLC9A4 →	+0.012	+3.607	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

KRTAP11-1 by AMZ1 expression — OVARY

Explore this box plot interactively →