AMY2B

Across TCGA patient cohorts, AMY2B mutation is significantly associated with the RNA expression of many other genes, with 3,558 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMY2B-associated genes across cancer lineages are SPRING1, VPS18, and LRRC59. Each is linked with AMY2B in more than 2 cancer types. Because this analysis shows association rather than direction, both AMY2B-to-partner and partner-to-AMY2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRING1 grouped by AMY2B-low versus AMY2B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMY2B→partner) and Y-score (partner→AMY2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPRING1 →	+0.535	+3.469	.008	.002	3	3
UCEC	VPS18 →	+0.441	+1.584	<.001	<.001	3	3
UCEC	LRRC59 →	+0.527	+1.776	<.001	<.001	3	3
UCEC	ZPR1 →	+0.257	+1.275	.008	.004	3	3
UCEC	MFN2 →	+0.384	+1.852	<.001	<.001	3	3
UCEC	XRCC3 →	+0.367	+1.716	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,558 associations by consensus.

SPRING1 by AMY2B expression — SKCM

Explore this box plot interactively →