AMY2B

Across TCGA patient cohorts, AMY2B mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMY2B-associated genes across cancer lineages are STAT3_pY705, TFRC, and Ku80. Each is linked with AMY2B in more than 2 cancer types. Because this analysis shows association rather than direction, both AMY2B-to-partner and partner-to-AMY2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by AMY2B-low versus AMY2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMY2B→partner) and Y-score (partner→AMY2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.243	-1.058	.001	.037	3	3
UCEC	TFRC →	+0.349	+2.000	.025	.029	3	3
UCEC	Ku80 →	+0.182	+1.254	.008	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.353	-1.514	.007	.014	3	2
UCEC	ASNS →	+0.369	+1.765	<.001	.011	3	2
UCEC	Bcl-2 →	-0.295	-2.150	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

STAT3_pY705 by AMY2B expression — UCEC

Explore this box plot interactively →