AMY2B

Across TCGA cell cohorts, AMY2B mutation is significantly associated with the RNA expression of many other genes, with 402 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMY2B-associated genes across cancer lineages are GFRA4, OR52E8, and OR2G6. Each is linked with AMY2B in more than 1 cancer types. Because this analysis shows association rather than direction, both AMY2B-to-partner and partner-to-AMY2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by AMY2B-low versus AMY2B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMY2B→partner) and Y-score (partner→AMY2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GFRA4 →	+0.036	+5.662	<.001	.002	3	2
LUNG_SCLC	OR52E8 →	+0.040	+4.643	<.001	.004	3	1
LUNG_SCLC	OR2G6 →	+0.075	+4.523	<.001	.003	3	1
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	KLHL40 →	+0.005	+3.865	.005	.001	3	1
OVARY	IQCF1 →	+0.278	+3.473	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 402 associations by consensus.

GFRA4 by AMY2B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →