AMY1B

Across TCGA pan-cancer cohorts, AMY1B RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AMY1B’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where AMY1B RNA is repressed in tumor relative to normal tissue. In most cancer types AMY1B is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.

BRCA, STAD, and CHOL are the cancer types where AMY1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMY1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.031	.004	6	view →
STAD	All	II,III,IV	+0.029	.012	4	view →
CHOL	Male	All	+0.026	.010	2	view →
LIHC	All	All	+0.005	.010	2	view →
LUSC	All	All	−0.037	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

AMY1B–BRCA

Open the BRCA breakdown →